Isaac Brown

Running BackRB
Questionable
Injury Lower Leg
Est. Return 12/23/2025
2025 Fantasy Outlook
Brown's 2025 season commenced with him working in a backfield committee alongside Maurice Turner, Keyjuan Brown, Duke Watson and Donald Chaney. By Week 5, Brown started to emerge as the top option in the backfield, amassing 13 carries for 72 yards and four grabs for 23 yards and a score in the contest. He served in more of a workhorse role down the stretch, handling at least 50 percent of the rushing attempts in five of the last games and 43 percent against Miami. The only two games he didn't? A game against Stanford in which he missed most of the game due to injury, and the subsequent week against Pitt in a blowout win. Watson is definitely an intriguing option behind Brown, but all signs point to Brown claiming a clear lead role in an explosive Cardinals offense in 2025, which should result in an improvement on his 147 carries for 1,074 yards and 11 touchdowns and 30 grabs for 152 yards and a score over the 12 regular-season contests last season, making him a top-flight fantasy running back option. Read Past Outlooks
Out for Week 14
Lower Leg
November 29, 2025
Brown (lower leg) is out for Saturday's game against Kentucky, Pete Thamel of ESPN reports.
ANALYSIS
Thamel announced that Louisville's team is without all four of its scholarship running backs, Brown being their top guy among them. Though not qualified to compete for the ACC Championship, the Cardinals are bowl eligible, meaning they can compete in one more game before their 2025 season officially comes to a close.
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Recent RotoWire Articles Featuring Isaac Brown See More
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More Fantasy News
Questionable for Week 14
Lower Leg
November 29, 2025
Brown (lower leg) is questionable for Saturday's game against Kentucky, Pete Nakos of On3.com reports.
ANALYSIS
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Out for Week 13
Lower Leg
November 20, 2025
Brown (lower leg) is out for Saturday's game at SMU, Pete Nakos of On3 reports.
ANALYSIS
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Remains out Friday
Lower Leg
November 12, 2025
Brown (lower leg) did not appear on the teams injury report but will still not play in Friday's game versus Clemson, Matt McGavic of SI.com reports.
ANALYSIS
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Absent from injury report
Lower Leg
November 12, 2025
Brown (lower leg) isn't listed on Louisville's injury report ahead of a Friday night showdown with Clemson.
ANALYSIS
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Will be out a while
Lower Leg
November 3, 2025
Brown (lower leg) will be out for a while, Matt McGavic of Sports Illustrated reports.
ANALYSIS
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