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Santana surrendered one hit and zero walks while striking out one batter in a scoreless ninth inning to collect a save in Wednesday's 3-0 win over the Angels.
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Heaney (2-1) earned the win Wednesday against the Angels, allowing one hit and zero walks while striking out nine batters across six shutout innings.
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Pham went 1-for-4 with an RBI on Wednesday against the Angels.
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Bednar struck out two without allowing a baserunner in a scoreless seventh inning to earn a hold Wednesday against the Angels.
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Mayza (shoulder) will be shut down from throwing for roughly six weeks, Colin Beazley of the Pittsburgh Post-Gazette reports.
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McCutchen went 2-for-5 with a three-run home run and a walk in Tuesday's win over the Angels.
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Reynolds went 3-for-5 with two RBI, two runs scored and a walk in Tuesday's win over the Angels.
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Falter was removed from his start Tuesday against the Angels due to lower-back tightness.
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Valdez (shoulder) will start at first base and bat fourth Tuesday against the Angels.
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Johnson (knee) went 2-for-5 with a double and one run scored during Sunday's game against Double-A Somerset.
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Horwitz (wrist) has been cleared for baseball activity and will participate in extended spring training, MLB.com reports.
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Santana (0-1) allowed one unearned run without allowing a hit to take the loss Sunday against the Guardians.
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Valdez (shoulder) went 0-for-2 with a walk and a run scored Sunday against the Guardians.
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Frazier went 1-for-4 with a double, two RBI and a run scored Sunday against the Guardians.
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Keller did not factor into the decision Sunday against the Guardians, pitching five two-run innings while allowing five hits and two walks. He struck out three.
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GM Ben Cherington said Valdez's shoulder injury is "relatively minor" and that the infielder could be available off the bench for Sunday's game versus the Guardians, Alex Stumpf of MLB.com reports.
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Cruz is out of the lineup for Sunday's game against the Guardians, Danny Demilio of PittsburghBaseballNow.com reports.
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Bednar allowed two hits and struck out two in a scoreless ninth inning Saturday against the Guardians.
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Skenes (2-2) took the loss against the Guardians on Saturday. He allowed two runs on six hits and one walk while striking out four across seven innings.
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Cruz went 1-for-3 with one walk and a stolen base in Saturday's 3-0 loss to the Guardians.
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Holderman (knee) will start his rehab assignment with Triple-A Indianapolis on Saturday, Danny Demilio of PittsburghBaseballNow.com reports.
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The Pirates placed Mayza on the 15-day injured list Saturday due to a left shoulder lat muscle strain, Noah Hiles of the Pittsburgh Post-Gazette reports.
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The Pirates recalled Bednar from Triple-A Indianapolis on Saturday, Noah Hiles of the Pittsburgh Post-Gazette reports.
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Kiner-Falefa is not in Pittsburgh's starting lineup against Cleveland on Saturday.
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Bart is not in the Pirates' starting lineup against the Guardians on Saturday.
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