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Seahawks vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
23.5 Pts
Seahawks
22.0 Pts
Sunday September 7, 2025 at 4:05 PM ET
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SF
49ers Injury Report
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SEA
Seahawks Injury Report
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SF
49ers Lineup
Inactives
    None reported yet.
SEA
Seahawks Lineup
Inactives
    None reported yet.
SF
49ers News
#3 SLB
Curtis Robinson: Activated off PUP list
Aug 2nd
The 49ers activated Robinson (undisclosed) off the active/PUP list Saturday, Vic Tafur of The Athletic reports.
#2 RB
Isaac Guerendo: Exits practice with apparent injury
Aug 2nd
Guerendo had an early departure from practice Saturday due to an apparent shoulder injury, Jennifer Lee Chan of NBC Sports Bay Area reports.
#6 WR
Jordan Watkins: Expected back at practice
Aug 2nd
Watkins (undisclosed) is expected to return to practice Saturday, Matt Maiocco of NBC Sports Bay Area reports.
#1 LG
Ben Bartch: Activated from NFI list
Jul 31st
Bartch (quadriceps) was activated from the active/non-football injury list by the 49ers on Thursday.
#1 LCB
Deommodore Lenoir: Missing time with hip injury
Jul 31st
Lenoir is expected to miss the next few practices with a hip injury, David Lombardi of SFStandard.com reports.
#12 WR
Andy Isabella: Signs with San Francisco
Jul 31st
The 49ers signed Isabella to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#11 WR
Marquez Callaway: Finds work with San Francisco
Jul 31st
The 49ers signed Callaway to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#5 QB
Carter Bradley: Joins San Francisco
Jul 31st
The 49ers signed Bradley to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#4 RB
Ameer Abdullah: Signs with San Francisco
Jul 31st
The 49ers signed Abdullah to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#3 RB
Jordan James: Misses practice with knee injury
Jul 31st
San Francisco head coach Kyle Shanahan said Thursday that James is not practicing due to "knee issues," Eric Branch of the San Francisco Chronicle reports.
#2 WR
Jauan Jennings: Calf injury an aggravation
Jul 31st
San Francisco coach Kyle Shanahan said Thursday that Jennings (calf) is dealing with an aggravation of the injury he dealt with during spring activities, Clayton Holloway of NFL Network reports.
#1 RT
Colton McKivitz: Returns from injury
Jul 31st
McKivitz (undisclosed) is fully healthy and participated in training camp Wednesday, Mike Maynard reports.
#3 RCB
Darrell Luter: Participating in training camp
Jul 31st
Luter (pelvis) has been participating in training camp, Grant Cohn of Sports Illustrated reports.
#3 RDE
Robert Beal: Clear of injury
Jul 31st
Beal (ankle) was a full participant in practice Tuesday, Grant Cohn of Sports Illustrated reports.
#2 DT2
Alfred Collins: Back at training camp
Jul 30th
Collins (calf) has fully participated in practices during the 49ers' first week of training camp, Mike Maynard of The Sporting News reports.
#1 SS
Ji'Ayir Brown: Recovered from ankle injury
Jul 30th
Brown (ankle) has participated in practices during the 49ers' first week of training camp, Jerry McDonald of The Mercury News reports.
#1 WR
Brandon Aiyuk: Keeping busy on sidelines
Jul 30th
San Francisco offensive coordinator Klay Kubiak said Tuesday that Aiyuk (knee), who remains on the active/PUP list, has been "kind of a coach on the side" throughout the early stages of training camp, Nick Wagoner of ESPN reports.
#9 WR
Russell Gage: Healthy start to camp
Jul 29th
Gage made an athletic grab during Tuesday's padded practice session, Matt Barrows of The Athletic reports.
#5 RDE
Tarron Jackson: Placed on IR
Jul 29th
The 49ers placed Jackson (undisclosed) on injured reserve Tuesday.
#1 LDE
Mykel Williams: Dealing with minor ankle injury
Jul 29th
Williams (ankle) did not participate in Tuesday's practice, Nick Wagoner of ESPN.com reports.
#2 RCB
Eli Apple: Signs with San Francisco
Jul 27th
Apple and the 49ers agreed on a one-year contract Sunday, Adam Schefter of ESPN reports.
#1 WLB
Dee Winters: Competing for starting role in camp
Jul 27th
Winters drew praise from a star teammate at the start of training camp as the linebacker prepares to compete for a starting role in 2025, Vic Tafur of The Athletic reports.
#5 WR
Jacob Cowing: Hopeful to return in 2-3 weeks
Jul 27th
San Francisco coach Kyle Shanahan said Sunday that he's hopeful Cowing (hamstring) will be back by the week of Aug. 11 for joint practices with the Raiders, David Lombardi of SFStandard.com reports.
#1 RCB
Renardo Green: Will be out several weeks
Jul 27th
Green (hamstring) is expected to be sidelined for the next several weeks, David Lombardi of SFStandard.com reports.
#3 WR
Ricky Pearsall: Activated from PUP list
Jul 27th
The 49ers activated Pearsall (hamstring) from the active/PUP list Sunday.
#1 K
Jake Moody: Facing competition for job
Jul 23rd
Moody is competing with Greg Joseph for San Francisco's placekicker job, David Lombardi of SFStandard.com reports.
#1 RB
Christian McCaffrey: Looking healthy at start of camp
Jul 22nd
Coach Kyle Shanahan said Tuesday that McCaffrey is "here and healthy" for the start of 49ers training camp, but the running back's workload will be managed in advance of the regular season, Nick Wagoner of ESPN.com reports.
SEA
Seahawks News
#2 SS
Nick Emmanwori: Lining up all over formation
Aug 2nd
Emmanwori is practicing at safety, nickel corner and outside linebacker, Gregg Bell of The Tacoma News Tribune reports.
#1 RILB
Ernest Jones: Back in action
Aug 1st
Jones (knee/personal) returned to practice Friday, Gregg Bell of The Tacoma News Tribune reports.
#4 WR
Tory Horton: Works with first-team offense
Aug 1st
Horton worked with the first-team offense Friday, Gregg Bell of The Tacoma News Tribune reports.
#1 LT
Charles Cross: Undergoes finger surgery
Jul 31st
Cross underwent surgery Thursday to repair a dislocated finger but is expected to be ready for the Seahawks' Week 1 season opener against the 49ers, Ian Rapoport of NFL Network reports.
#4 RB
George Holani: Competing for No. 3 job
Jul 29th
Holani is competing for the No. 3 running back job after Kenny McIntosh suffered a torn ACL on Monday, Michael-Shawn Dugar of The Athletic reports.
#1 NT
Byron Murphy: Aiming for more pass-rushing work
Jul 29th
Murphy (back) is expected to be a bigger factor as a pass rusher in 2025, John Boyle of the Seahawks' official site reports.
#3 RB
Damien Martinez: Seeking No. 3 role
Jul 29th
Martinez is competing for the No. 3 running back role after Kenny McIntosh suffered a torn ACL on Monday, Michael-Shawn Dugar of The Athletic reports.
#6 RB
D.K. Kaufman: Catches on with Seattle
Jul 28th
The Seahawks signed Kaufman to a contract Monday, Curtis Crabtree of Fox 13 Seattle reports.
#7 RB
Kenny McIntosh: Placed on IR
Jul 28th
The Seahawks placed McIntosh (knee) on injured reserve Monday, Curtis Crabtree of Fox 13 Seattle reports.
#2 TE
Elijah Arroyo: Competing with AJ Barner
Jul 28th
Arroyo is thriving as a pass catcher early in training camp, but AJ Barner's blocking makes him the favorite to replace Noah Fant as Seattle's starting tight end, according to Gregg Bell of The Tacoma News Tribune.
#2 RB
Zach Charbonnet: Sharing backfield with Walker again
Jul 24th
Charbonnet and Kenneth Walker give Seattle backfield continuity in an otherwise revamped offense, ESPN.com's Brady Henderson reports.
#1 FB
Robbie Ouzts: Runs with first-team offense
Jul 23rd
Ouzts worked with the first-team offense during the Seahawks' first day of training camp Wednesday, Gregg Bell of The News Tribune reports.
#2 RCB
Shaquill Griffin: Sidelined by illness
Jul 23rd
Griffin did not practice Wednesday due to an illness, Michael-Shawn Dugar of The Athletic reports.
#2 SLB
Uchenna Nwosu: Not close to returning
Jul 23rd
Nwosu (knee) is not expected to be ready to practice anytime soon, Brady Henderson of ESPN.com reports.
#2 NT
Johnathan Hankins: Dealing with back injury
Jul 23rd
The Seahawks placed Hankins (back) on the active/non-football injury list Wednesday, Aaron Wilson of KPRC 2 Houston reports.
#1 RB
Kenneth Walker: Back to 100 percent
Jul 23rd
Coach Mike Macdonald said Wednesday that Walker (ankle) was a full practice participant to begin training camp, Brady Henderson of ESPN.com reports. "He looks great. He's in a great spot mentally," Macdonald added. "Awesome to see him do all the things we want him to do from the get-go. I know he's really excited about what's going on. Great first day with Ken."
#1 QB
Sam Darnold: Starting QB heading into camp
Jul 23rd
Darnold will take the first-team quarterback reps when training camp starts Wednesday, and there isn't a quarterback competition with rookie third-round pick Jalen Milroe, Brady Henderson of ESPN.com reports.
#1 TE
AJ Barner: Opportunity awaits
Jul 21st
Barner will compete with rookie Elijah Arroyo for the starting tight end job after the Seahawks released Noah Fant on Sunday, Bob Condotta of The Seattle Times reports.