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Seahawks vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
Seahawks
Saturday January 17, 2026 at 8:00 PM ET
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SF
49ers Injury Report
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SEA
Seahawks Injury Report
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SF
49ers Lineup
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SEA
Seahawks Lineup
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SF
49ers News
#2 WR
Ricky Pearsall: No catches in return
Jan 17th
Pearsall did not record a catch on two targets in Saturday's 41-6 divisional-round loss to the Seahawks.
#1 WR
Jauan Jennings: Quiet to close campaign
Jan 17th
Jennings recorded two receptions on five targets for 39 yards in Saturday's divisional-round loss to the Seahawks.
#1 QB
Brock Purdy: Struggles against Seattle
Jan 17th
Purdy completed 15 of 27 passes for 140 yards, no touchdowns and one interception in Saturday's 41-6 divisional-round loss to the Seahawks. He added five rushes for 37 yards but lost a fumble.
#1 RB
Christian McCaffrey: Limited in loss
Jan 17th
McCaffrey rushed the ball 11 times for 35 yards in Saturday's 41-6 divisional-round loss to the Seahawks. He added five receptions on six targets for 39 yards.
#1 TE
Jake Tonges: Suffers foot injury
Jan 17th
Tonges is questionable to return to Saturday's divisional-round game against the 49ers due to a foot injury, Eric Williams of NFL on FOX reports.
#1 SLB
Luke Gifford: Gearing up Saturday
Jan 17th
Gifford (quadriceps) will play in Saturday's divisional-round game versus the Seahawks.
#1 WLB
Dee Winters: Good to go Saturday
Jan 17th
Winters (ankle) is active for Saturday's divisional-round matchup versus the Seahawks, Briana Jeannel of the 49ers' official site reports.
#10 WR
Jacob Cowing: Ruled out vs. Seahawks
Jan 17th
Cowing (hamstring) has been ruled out for San Francisco's divisional-round matchup versus the Seahawks on Saturday.
#2 LDE
Yetur Gross-Matos: Green light to play Saturday
Jan 15th
Gross-Matos (knee) does not carry an injury designation into Saturday's NFC divisional-round clash against Seattle.
#1 RG
Dominick Puni: Cleared to play vs. Seattle
Jan 15th
Puni (ankle) does not carry an injury designation into Saturday's NFC divisional-round game against the Seahawks.
#1 SS
Ji'Ayir Brown: Won't play vs. Seattle
Jan 15th
Brown (hamstring) has been ruled out for Saturday's NFC divisional-round clash against the Seahawks, Briana Jeannel of the 49ers' official site reports.
#2 MLB
Fred Warner: Won't return for divisional round
Jan 15th
Warner (ankle) has been ruled out for Saturday's NFC divisional-round clash against the Seahawks, Briana Jeannel of the 49ers' official site reports.
#1 LT
Trent Williams: Full participant in practice
Jan 14th
Williams (hamstring) was a full participant in San Francisco's practice Wednesday, Cam Inman of The San Jose Mercury News reports.
#3 TE
Brayden Willis: Signs to active roster
Jan 14th
The 49ers elevated Willis from the practice squad to the active roster.
#4 TE
George Kittle: Officially placed on IR
Jan 14th
The 49ers placed Kittle (Achilles) on injured reserve Wednesday.
#7 WR
Colton Dowell: Signed to future deal
Jan 14th
The 49ers signed Dowell to a reserve/future contract Wednesday.
#3 WR
Demarcus Robinson: Leading receiver in WC win
Jan 11th
Robinson corralled six of seven targets for 111 yards and a touchdown in Sunday's 23-19 wild-card win over Philadelphia.
#3 LDE
Keion White: Will play versus the Eagles
Jan 11th
White (groin/hamstring) is active for Sunday's wild-card game versus Philadelphia.
#1 LCB
Renardo Green: Good to go for wild-card contest
Jan 11th
Green (ankle) is active for Sunday's wild-card matchup versus the Eagles.
#9 WR
Malik Turner: Elevated to active roster
Jan 10th
The 49ers elevated Turner to the active roster from their practice squad Saturday ahead of Sunday's wild-card matchup versus the Eagles.
#1 LDE
Bryce Huff: Records four sacks with SF
Jan 10th
Huff appeared in 15 games for the 49ers in 2025 and finished the regular season with 30 tackles (14 solo), 4.0 sacks and two forced fumbles.
#1 RCB
Deommodore Lenoir: Logs over 1,000 snaps on defense
Jan 9th
Lenoir finished the 2025 regular season with 61 tackles (39 solo) and two interceptions across 17 starts.
#1 FS
Malik Mustapha: Strong return from surgery in 2025
Jan 9th
Mustapha logged 76 combined tackles (44 solo) and defended three passes (including one interception) across 12 regular-season starts in 2025.
#1 SCB
Upton Stout: Takes over as slot CB in first year
Jan 8th
Stout finished with 82 tackles (43 solo), 1.0 sacks and one forced fumble across 16 regular-season games in 2025.
#6 WR
Jordan Watkins: Little involvement in rookie year
Jan 8th
Watkins was active for four games in 2025 and finished the regular season with two receptions on three targets for 26 yards.
#5 WR
Skyy Moore: Finds home in SF as return man
Jan 8th
Moore finished the 2025 regular season with five receptions for 87 yards, two carries for 11 yards and 1,198 combined return yards in 17 appearances.
#3 RB
Jordan James: Gets some late run on ST
Jan 7th
James did not record a touch while appearing in three games for the 49ers in 2025.
#2 TE
Luke Farrell: Finds end zone in fifth year
Jan 7th
Farrell finished his first regular season with San Francisco grabbing 11 of 14 targets for 85 yards and two touchdowns across 17 games.
#4 RB
Isaac Guerendo: Falls out of favor in 2025
Jan 7th
Guerendo was only utilized on special teams this season, finishing with 100 kick return yards across 14 active games.
#2 QB
Mac Jones: Thrives as Purdy's backup in 2025
Jan 7th
Jones finished the regular season completing 70 percent of his pass attempts for 2,151 yards, 13 touchdowns and six interceptions across 11 games.
#3 MLB
Tatum Bethune: Moved to IR
Jan 7th
The 49ers placed Bethune (groin) on injured reserve Wednesday.
#1 MLB
Eric Kendricks: Signs to active roster
Jan 7th
The 49ers signed Kendricks from the practice squad to the active roster Wednesday.
#1 K
Eddy Pineiro: Provides only offense for SF
Jan 4th
Pineiro converted his only field-goal attempt of 48 yards in Saturday's 13-3 loss to Seattle.
#4 WR
Kendrick Bourne: Non-factor in Saturday's loss
Jan 4th
Bourne failed to catch his only target in Saturday's 13-3 loss to the Seahawks.
#2 RB
Brian Robinson: Just two carries in loss to SEA
Jan 4th
Robinson rushed two times for nine yards and was not targeted as a receiver in Saturday's 13-3 loss to Seattle.
#2 WLB
Curtis Robinson: Healthy scratch again
Jan 3rd
Robinson (coach's decision) is inactive for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports.
SEA
Seahawks News
#2 WR
Cooper Kupp: Solid showing on five targets
Jan 17th
Kupp recorded five receptions on five targets for 60 yards in Saturday's 41-6 divisional-round win over the 49ers.
#3 WR
Rashid Shaheed: Kicks off rout of 49ers
Jan 17th
Shaheed did not record a catch on two targets in Saturday's 41-6 divisional-round win over the 49ers. He added two rushes for 27 yards and two kick returns for 126 yards and a touchdown.
#1 QB
Sam Darnold: Effective despite injury
Jan 17th
Darnold completed 12 of 17 passes for 124 yards and a touchdown in Saturday's 41-6 divisional-round win over the 49ers.
#1 WR
Jaxon Smith-Njigba: Scores in blowout win
Jan 17th
Smith-Njigba recorded three receptions on four targets for 19 yards and a touchdown in Saturday's 41-6 divisional-round win over the 49ers.
#1 RB
Kenneth Walker: Three scores in blowout win
Jan 17th
Walker rushed the ball 19 times for 116 yards and three touchdowns in Saturday's 41-6 divisional-round win over the 49ers. He added three receptions on three targets for 29 yards.
#3 RB
Zach Charbonnet: Set for imaging
Jan 17th
Charbonnet will get imaging done on his knee after departing Saturday's NFC divisional-round game against the 49ers, John Boyle of the Seahawks' official site reports.
#1 LT
Charles Cross: Suffers foot injury
Jan 17th
Cross exited Saturday's divisional-round game versus the 49ers with a foot injury and is considered questionable to return, Corbin K. Smith of SI.com reports.
#2 QB
Drew Lock: Remains No. 2 with Darnold active
Jan 17th
Lock is poised to remain the backup QB behind Sam Darnold (oblique) after the latter was deemed active for Saturday's divisional-round game against the 49ers, John Boyle of the Seahawks' official site reports.
#3 QB
Jalen Milroe: Emergency QB vs. 49ers
Jan 17th
Milroe (coach's decision) is inactive but will serve as the emergency third quarterback for Saturday's divisional-round matchup versus San Francisco.
#2 MLB
Tyrice Knight: Good to go for divisional round
Jan 15th
Knight (shoulder) does not carry an injury designation into Saturday's NFC divisional-round tilt against the 49ers, Brady Henderson of ESPN.com reports.
#2 WLB
Tyrice Knight: Good to go for divisional round
Jan 15th
Knight (shoulder) does not carry an injury designation into Saturday's NFC divisional-round tilt against the 49ers, Brady Henderson of ESPN.com reports.
#2 LT
Josh Jones: Won't play in divisional round
Jan 15th
Jones (knee) has been ruled out for Saturday's NFC divisional-round game against the 49ers, Curtis Crabtree of Fox 13 Seattle reports.
#1 MLB
Ernest Jones: Cleared to play Saturday
Jan 15th
Jones (illness) does not carry an injury designation into Saturday's NFC divisional-round tilt against San Francisco.
#4 TE
Elijah Arroyo: Staying on IR for divisional round
Jan 15th
Arroyo (knee) has been ruled out for Saturday's NFC divisional-round game against the 49ers, John Boyle of the Seahawks' official site reports.
#2 RCB
Riq Woolen: Good to go for divisional round
Jan 15th
Woolen (oblique) does not carry an injury designation into Saturday's NFC divisional-round game against the 49ers, Brady Henderson of ESPN.com reports.
#1 LDE
DeMarcus Lawrence: Full participant in practice
Jan 14th
Lawrence (Achilles) was a full participant in Seattle's practice Wednesday, Michael-Shawn Dugar of The Athletic reports.
#1 SS
Coby Bryant: Past knee injury
Jan 13th
Bryant (knee) was a full participant in Tuesday's practice, John Boyle of the Seahawks' official site reports.
#1 RDE
Derick Hall: Notches sack in return
Jan 5th
Hall recorded 1.0 sacks on his only tackle in Saturday's 13-3 win over the 49ers.
#2 DT2
Jarran Reed: Records 2.5 sacks in 2025
Jan 5th
Reed recorded two solo tackles, including 1.0 sacks, in Saturday's 13-3 win over the 49ers.
#2 TE
Eric Saubert: Handles increased workload
Jan 5th
Saubert caught two of three targets for 10 yards in Saturday's 13-3 win over the 49ers.
#1 K
Jason Myers: Misses two kicks in win
Jan 5th
Myers connected on two of four field-goal attempts and his lone extra-point try in Saturday's 13-3 win over the 49ers.
#1 TE
AJ Barner: Snares two passes in win
Jan 5th
Barner caught two of three targets in Saturday's 13-3 win over the 49ers.
#4 WR
Jake Bobo: No targets once again
Jan 5th
Bobo wasn't targeted in Saturday's 13-3 win over the 49ers.