Hotspots on the Week 12 NFL injury report include Chicago's linebackers, Detroit's offensive line and secondary, the Giants' secondary, Tennessee's receiving corps and Atlanta's... everything. Make sure to keep up with NFL breaking news throughout the weekend, especially Sunday morning when inactive lists are released at 11:30 a.m. ET for the early games. There are a handful of potential game-time decisions with potential to have a huge impact on Week 12 NFL projections.
Below you'll find four different categories, with our lists including key offensive linemen and defensive players whose absences might impact fantasy decisions. The bottom section, for potential game-day decisions, is sorted by kickoff times. It can be used as a checklist/cheatsheet for Sunday morning and afternoon when inactives come out and we need to adjust lineups.
Good to Go 💯
Players that missed their team's previous game are listed in bold.
Cleared to Play this Week
QB Baker Mayfield (illness)
QB Lamar Jackson (ankle)
QB Daniel Jones (fibula)
RB D'Andre Swift (hip)
RB Jaylen Warren (ankle)
WRs Romeo Doubs (knee) & Christian Watson (knee)
WR Darius Slayton (hamstring)- WRs Emeka Egbuka (illness) & Sterling Shepard (shoulder)
WR Kayshon Boutte (hamstring)
WR Chimere Dike (chest)
WR Xavier Legette (hip)
WR Kalif Raymond (cramps)
TE David Njoku (knee)
TE Mike Gesicki (pectoral)- TE Austin Hooper (concussion)
Ruled Out/Doubtful 🚑
New absences listed in bold (guys that played in the previous game).
Out/Doubtful/IR
- QB Dillon Gabriel (concussion)
- QB Jaxson Dart (concussion)
QB Michael Penix (IR - ACL)- RB Bucky Irving (toe/shoulder)
RB Isiah Pacheco (knee)
RBs Trey Benson (IR - knee) & Emari Demercado (high ankle)- RBs Roschon Johnson (hand) & Travis Homer (leg)
- RB Samaje Perine (D - high ankle)
WR Brian Thomas (high ankle)- WR Marvin Harrison (appendix)
- WRs Elic Ayomanor (hamstring) & Calvin Ridley (IR - leg)
- WR Drake London (PCL)
- WR Rashod Bateman (ankle)
WR Tory Horton (groin)- WR Jamari Thrash (foot)
- TE Hunter Long (hip/knee)
TE Tyler Higbee (IR - ankle)
Potential Workload Beneficiaries (From Injuries Above)
- QB Shedeur Sanders
- QB Jameis Winston
- QB Kirk Cousins
- RBs Sean Tucker & Rachaad White
- RB Kareem Hunt
- RBs Bam Knight & Michael Carter
- WRs Jakobi Meyers, Parker Washington & Tim Patrick
- WRs Michael Wilson, Greg Dortch & Xavier Weaver
- WRs Chimere Dike, Van Jefferson & Mason Kinsey
- WRs Darnell Mooney, KhaDarel Hodge & David Sills + TE Kyle Pitts
- WR DeAndre Hopkins
- WR Isaiah Bond
- TEs Colby Parkinson, Terrance Ferguson & Davis Allen
Key Defensive Players + Offensive Linemen
- DE Trey Hendrickson (hip)
- OLB Alex Highsmith (pectoral)
- DT Cameron Heyward (ankle), G Isaac Seumalo (pec), CB Darius Slay (head)
- LB T.J. Edwards (hand), LB Tremaine Edmunds (groin), LB Noah Sewell (elbow)
- CB Paulson Adebo (knee), OLB Kayvon Thibodeaux (shoulder)
- CB Terrion Arnold (head), S Kerby Joseph (knee)
- CB Nate Hobbs (knee), LB Quay Walker (stinger)
- LB Tyrice Knight (concussion)
- S Xavier Woods (hamstring), S Kendell Brooks (head)
- RT Anton Harrison (knee), DE Travon Walker (knee)
RT Lane Johnson (foot)- SCB Billy Bowman (Achilles), DE Zach Harrison (knee)
- G Ben Bredeson (hamstring), CB Jamel Dean (hip), OLB Haason Reddick (ankle)
MLB Tatum Bethune (ankle)- ILB Christian Rozeboom (hip)
The #Bears linebacking corps is decimated for Sunday. Edmunds, Edwards and Sewell all OUT.
More encouraging news in the secondary with Johnson and Gordon both full participants in today's practice and QUESTIONABLE to face the #Steelers. https://t.co/A3a1e2fowj
— Mike Berman (@MikeBermanNBC) November 21, 2025
Listed as Questionable - Should Play 👍
RB Alvin Kamara (ankle)- RB Kenneth Walker (glute)
Ken Walker III is listed questionable with a glute injury but he's fine to play Sunday, Mike Macdonald says
— Dugar, Michael-Shawn (@MikeDugar) November 21, 2025
Truly Questionable / Game-Time Decisions 🤔
Players with key fantasy repercussions listed in bold.
Early Games
- QB Joe Burrow (toe)
- QB Aaron Rodgers (wrist)
- RB Josh Jacobs (knee)
- RB Rhamondre Stevenson (toe)
- WR Xavier Worthy (ankle)
- WRs Matthew Golden (wrist), Dontayvion Wicks (calf) & Savion Williams (foot)
- WR Isaac TeSlaa (oblique)
Burrow, Rodgers, Jacobs and Stevenson all appear truly questionable. For Jacobs, the matchup with Detroit on Thanksgiving could be a consideration, though any division game is huge for the Packers at this point. Jacobs has a strong track record of playing through injuries and remaining productive.
Late-Afternoon Games
- TE Brenton Strange (IR - hip)
Jaguars rule out DE Travon Walker, WR Brian Thomas Jr., RT Anton Harrison, TE Hunter Long, and LB Yasir Abdullah for Sunday's game at Arizona. pic.twitter.com/thwbLBaBjd
— Michael DiRocco (@ESPNdirocco) November 21, 2025
Primetime Games
- WR Chris Godwin (fibula) - SNF
- WR Xavier Smith (concussion) - SNF
Bowles says Chris Godwin is trending on playing Sunday vs. Rams.
— Greg Auman (@gregauman) November 21, 2025
Key Defensive Players + O-Linemen
- OLB Harold Landry (knee)
- RG Jalen Rivers (knee)
- CB Jaylon Johnson (groin), CB Kyler Gordon (calf), S Jaquan Brisker (shoulder)
- CB Deonte Banks (hip), S Tyler Nubin (neck)
- CB D.J. Reed (hamstring), DE Marcus Davenport (shoulder)
- T Taylor Decker (arm), G Graham Glasgow (knee), G Tate Ratledge (knee), T Penei Sewell (leg)
DE Will McDonald (quad), DT Harrison Phillips (foot)
C Ryan Kelly (IR - concussion), OLB Jonathan Greenard (shoulder)- LB Ernest Jones (knee), G Grey Zabel (knee)
- CB Darrell Baker (knee)
- G Kingsley Suamataia (concussion)
- RT Jack Conklin (knee)
- OT Kelvin Beachum (groin)
- CB Garrett Williams (ankle), CB Will Johnson (back), DE Darius Robinson (groin)
- CB Jarrian Jones (quad), CB Jourdan Lewis (neck)
- RG Chris Lindstrom (foot), LG Matthew Bergeron (ankle), DE Leonard Floyd (hamstring)
- RT Taliese Fuaga (ankle)
- LB Trevin Wallace (shoulder)
