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Derrick Henry
Passes Jim Brown on TD list
Henry surpassed Jim Brown by scoring his 107th career rushing touchdown in the first half of Sunday night's game against the Bills.
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DJ Giddens
Chance for increased role
Giddens would serve as Indianapolis' RB2 behind Jonathan Taylor for Sunday's game against Miami if Tyler Goodson is unable to play due to an elbow injury, Amanda Foster of the Colts' official site reports.
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Kyle Monangai
Bears' RB2 in Week 1?
Monangai would be slated to serve as the Bears' backup running back behind D'Andre Swift against the Vikings on Monday if Roschon Johnson is unable to play due to a foot injury.
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Ollie Gordon
Slotting in as RB2 in Week 1
Gordon is set to occupy the second spot on Miami's running back depth chart against the Colts in Week 1, as De'Von Achane doesn't have an injury designation while Jaylen Wright has been ruled out due to a knee injury, per Travis Wingfield of the Dolphins' official site.
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Javonte Williams
Seizes control of Dallas backfield
Williams rushed 15 times for 54 yards and two touchdowns in Thursday's 24-20 loss to the Eagles.
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Jaydon Blue
Scratched for Week 1
Blue is listed as inactive for Thursday's game against the Eagles due to a coach's decision.
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Jacory Croskey-Merritt
Fourth on initial depth chart
Croskey-Merritt is listed fourth on Washington's unofficial depth chart heading into the regular season.
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Omarion Hampton
Harris likely to draw Week 1 start
Hampton's backfield mate Najee Harris is expected to draw the start in Friday's Week 1 start against the Chiefs in Brazil despite having missed all of preseason, Nate Taylor of ESPN.com reports.
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Najee Harris
Week 1 start considered likely
Harris, who participated in Wednesday's practice, is expected to start Friday's game against the Chiefs in Brazil, Nate Taylor of ESPN.com reports.
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Jordan Mason
Ready to reach 1,000 yards?
Seth Walder of ESPN predicts that Mason will reach 1,000 rushing yards in 2025.
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Najee Harris
Expects to play in opener
Harris indicated Monday that he believes he'll be able to play Friday in the Chargers' season opener in Sao Paulo against Kansas City, Daniel Popper of The Athletic reports.
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British Brooks
Part of Mixon-less RB room
Brooks is one of five running backs that made Houston's 53-man roster after the team placed placed Joe Mixon on the reserve/non-football injury list Tuesday.
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Dare Ogunbowale
Early pass-catching role?
Ogunbowale could open the season as Houston's third-down back after the team placed placed Joe Mixon on the reserve/non-football injury list Tuesday.
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Ollie Gordon
Rookie-year impact projected
Bucky Brooks of NFL.com projects Gordon to outpace his sixth-round slotting in April's draft during his rookie campaign.
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De'Von Achane
GM optimistic for Week 1
General manager Chris Grier said Wednesday that the team expects Achane to suit up against the Colts in Week 1, per Joe Schad of The Palm Beach Post.
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Ollie Gordon
Injuries clear path for early role
Gordon is poised to begin the regular season as the top backup to De'Von Achane, as David Furones of the South Florida Sun Sentinel reports that Jaylen Wright is expected to miss multiple weeks after undergoing surgery on a leg injury.
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Julius Chestnut
Top healthy option behind Pollard
Chestnut is poised to begin the regular season as Tony Pollard's top backup, as the Titans officially placed Tyjae Spears on the injured reserve/designated for return list Tuesday due to an ankle injury.
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Najee Harris
Practices in pads Wednesday
Harris, who suffered an eye injury in a July 4 fireworks incident and was activated from the NFI list Tuesday, practiced in pads Wednesday for the first time since joining the Chargers, Kris Rhim of ESPN.com reports.
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Kendre Miller
Secures backup role
Miller enters the 2025 season as Alvin Kamara's backup, Katherine Terrell of ESPN reports.
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Nick Chubb
Appears set for starting role
Chubb is expected to be the starting running back for the Texans for at least the first four weeks of the season with Joe Mixon set to begin the campaign on the reserve/non-football injury list, Adam Schefter of ESPN reports.
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Hassan Haskins
Could begin season as team's RB2
Daniel Popper of The Athletic believes Haskins could open the regular season second on the Chargers' running back depth chart behind rookie Omarion Hampton.
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Tyler Badie
Projected to snag roster spot
Nick Kosmider of The Athletic predicts that Badie will make Denver's 53-man roster.
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Audric Estime
Projected cut per Kosmider
Nick Kosmider of The Athletic believes Estime won't make Denver's 53-man roster.
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Jaydon Blue
Hopeful for Week 1
Blue is hopeful to be available for Dallas' regular-season opener against the Eagles after suffering a low-ankle sprain in Friday's preseason finale against Atlanta, per Jeremy Fowler of ESPN.com.
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Elijah Mitchell
Not a lock for Chiefs' roster
Jesse Newell of The Athletic has Brashard Smith making the Chiefs' 53-man roster over Mitchell ahead of Tuesday's cutdown day.
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