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Bam Knight
In line for lead role
Knight is expected to serve as Arizona's lead back against the Colts in Week 6, according to Adam Schefter of ESPN.
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Jacoby Brissett
Could have multi-week starting run
Brissett could make multiple starts for the Cardinals, as Ian Rapoport of NFL Network reports that Kyler Murray could be sidelined multiple weeks by a mid-foot sprain that is "a version of a Lisfranc injury."
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Kyler Murray
Likely out Week 6, maybe beyond
Murray is dealing with a mid-foot sprain that is "a version of a Lisfranc injury," which could sideline him for multiple weeks, according to Ian Rapoport of NFL Network.
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Marvin Harrison
Offense capped sans Murray?
Harrison and the Cardinals will likely be without starting quarterback Kyler Murray for Sunday's game against the Colts due to a mid-foot sprain, Bobby Kownack of NFL.com reports.
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Jacoby Brissett
In play for Week 6 start
Brissett could make a spot start Week 6 against the Colts, as Kyler Murray didn't participate in practice Wednesday due to a foot injury, per Darren Urban of the Cardinals' official site reports.
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Trey Benson
New No. 1 back for Arizona
Benson will become the Cardinals' new starting running back for the rest of the year with Darren Urban of the team's official site reporting that James Conner will undergo season-ending foot surgery.
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Emari Demercado
Expanded role moving forward
Demercado is likely to work as the Cardinals' No. 2 running back beginning with Thursday's Week 4 matchup against the Seahawks following James Conner's season-ending ankle injury, Josh Weinfuss and Adam Schefter of ESPN report.
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James Conner
Season-ending injury feared
The ankle injury Conner suffered in Sunday's Week 3 loss to the 49ers is of the season-ending variety, Josh Weinfuss and Adam Schefter of ESPN report.
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Trey Benson
Set to lead Cardinals' backfield
Benson is set to take over as the Cardinals' RB1 after James Conner suffered a serious right ankle injury in Sunday's 16-15 loss to the 49ers, Josh Weinfuss of ESPN reports.
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Kyler Murray
Navigates social media controversy
Murray apologized Wednesday for a social media post that included a photo of him wearing a Michael Vick jersey while posing with one of his two bulldogs, Josh Weinfuss of ESPN.com reports.
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Will Johnson
Pushing for bigger role
Johnson impressed coach Jonathan Gannon during Sunday's Week 1 win over the Saints, Josh Weinfuss of ESPN reports.
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Zay Jones
Fellow Arizona WRs banged up
Jones is likely to see extensive first-team opportunities in training camp, as Cameron Cox of 12 Sports AZ reports that Michael Wilson has been placed in concussion protocol while Marvin Harrison is dealing with a knee injury and illness.
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Trey Benson
Co-RB1 with Conner?
Benson appears poised to see a larger role in his second season in the NFL, with James Conner saying Saturday, "[Benson's going to] play a lot this year," Tyler Drake of ArizonaSports.com reports.
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Marvin Harrison
Up to 220 pounds to open camp
Harrison has bulked up to 220 pounds after being listed at 209 during his rookie 2024 season, Josh Weinfuss of ESPN.com reports.
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Trey McBride
Ranked fourth among TEs
McBride was ranked the league's fourth-best tight end based on votes from a combination of NFL executives, scouts and coaches, per Jeremy Fowler of ESPN.com.
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Jalen Thompson
Might be final year in Arizona
The Cardinals don't appear to be willing to give Thompson a contract extension, Doug Haller of The Athletic speculates.
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Josh Sweat
Top-100 player after big Super Bowl
Sweat was voted 95th among the top 100 players of 2025 by his fellow players.
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Kyler Murray
Wowed by Harrison this offseason
Murray has recently expressed how much offseason improvement he feels 2024 first-round pick Marvin Harrison has made, Josh Weinfuss of ESPN.com reports.
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Marvin Harrison
Looks improved in offseason
Harrison appears to have made notable progress in his comfort level with the NFL game this offseason, Josh Weinfuss of ESPN.com reports.
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Kyler Murray
Looking to ad lib better
Murray has focused on improving when the offense gets off schedule during Arizona's offseason program, Josh Weinfuss of ESPN.com reports. "It's just we have to be better on off-scheduled plays because, obviously, I have that ability to make extend plays and we have the guys to go do it off schedule," Murray said. "So, I believe that's an area we got to be better at."
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Will Johnson
Out for Wednesday's minicamp
Johnson, whom the Cardinals selected out of Michigan in the second round of the 2025 NFL Draft, sat out Wednesday's minicamp session despite being in uniform, Josh Weinfuss of ESPN.com reports.
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Josh Sweat
Arizona's key offseason move
Mike Sando of The Athletic views signing Sweat as the best move the Cardinals made in the offseason.
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Max Melton
Opportunity knocks in coming season
Melton, a 2024 second-round pick, could see increased opportunity at outside cornerback in the coming season in the wake of Sean Murphy-Bunting being placed on the non-football injury list Thursday, The Associated Press and Josh Weinfuss of ESPN.com report.
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Sean Murphy-Bunting
Will miss all of 2025
Bunting was placed on the non-football injury list by the Cardinals on Thursday and will miss the entire 2025 season, The Associated Press and Josh Weinfuss of ESPN.com report.
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Marvin Harrison
Bulking up for Year 2
Harrison has added muscle this offseason but is still settling on finding a comfortable playing weight, Josh Weinfuss of ESPN.com reports.
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