Best 49ers vs Eagles NFL Picks and Parlays for Wild Card Round (2026)

The Wild Card Round is always one of the best times of the year to build NFL picks and parlays. If you're struggling to craft your bet slip for the San Francisco 49ers vs. Philadelphia Eagles game, I've got you covered. I've built easy NFL parlays for you to bet by pulling my favorite bets from the Best 49ers vs Eagles Player Props piece. Follow that link for a more in-depth analysis of the game. 

For a full look at this weekend's slate, check out RotoWire's Best NFL Wild Card Round Player Props. 

Note: All odds highlighted below were pulled at the time the article was written. 

Best NFL Parlay Today: 49ers vs Eagles Wild Card Round

Here is my favorite NFL parlay today for the 49ers-Eagles game. This section focuses entirely on player props. Note that odds will vary from sportsbook to sportsbook.

• Leg One: Christian McCaffrey – Rushing Yards: UNDER 61.5 (-115) 
• Leg Two: Brock Purdy – Passing Yards: OVER 228.5 (-114)
• Leg Three: Saquon Barkley – Rushing Yards: OVER 78.5 (-111) 
• 💰 Payout: $100 Bet Wins $667.13

Best NFL Parlays If You Pick the 49ers

If you think the 49ers are going to win, it's not going to be because of their defense. San Francisco will want to turn this one into a shootout and hope Philadelphia can't keep pace. Here's an NFL parlay built around the 49ers winning a high-scoring game, using odds you can find with a bet365 bonus code. 

• Leg One: San Francisco 49ers Moneyline (+198) 
• Leg Two: Total Points: OVER 44.5 (-105) 
• 💰 Payout: $100 Bet Wins $581.81

Best NFL Parlays If You Pick the Eagles 

If you like Philadelphia, you're probably expecting the loaded Eagles' defense to shutdown the 49ers' dangerous offense. Here's an NFL parlay built around Philadelphia limiting San Francisco and winning a low-scoring game, using odds you can find with a BetMGM bonus code. 

• Leg One: Philadelphia Eagles Point Spread: -4.5 (-120) 
• Leg Two: Total Points: UNDER 44.5 (-115) 
• 💰 Payout: $100 Bet Wins $342.75

Easy NFL Parlays for 49ers vs Eagles: Wild Card Round 

Sometimes, it's best not to overthink it. The 49ers roster has been decimated by injuries, and the Eagles have one of the most loaded top-to-bottom lineups in the league. San Francisco can't tackle Saquon Barkley and Philadelphia is going to win this one. Here's a simple, easy NFL parlay you can bet to capitalize on that, using odds you can find with a Caesars Sportsbook promo code. 

• Leg One: Philadelphia Eagles Moneyline (-240)
• Leg Two: Saquon Barkley – Rushing Yards: OVER 78.5 (-111)
• 💰 Payout: $100 Bet Wins $269.29

Where to Bet on Wild Card Round Parlays

Below, I've provided a list of the top sportsbooks that offer parlays. I've also provided the sign-up bonus at each book, so you can make the most of your prop bets.