San Francisco 49ers vs Arizona Cardinals Odds, Week 3, 2025

#1 RDE

Nick Bosa: Won't return vs. Arizona

Sep 21st

Bosa (knee) has been ruled out for the rest of Sunday's game against the Cardinals, Matt Maiocco of NBC Sports Bay Area reports.

#1 LDE

Mykel Williams: Questionable to return Week 3

Sep 21st

Williams is questionable to return to Sunday's game against the Cardinals due to a wrist injury, Matt Barrows of The Athletic reports.

#1 LG

Connor Colby: Will start for SF on Sunday

Sep 21st

Colby (groin) is active for Sunday's Week 3 clash against the Cardinals, Briana Jeannel of the 49ers' official site reports.

#4 RB

Jordan James: Won't play against Arizona

Sep 21st

James (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports.

#2 QB

Mac Jones: Another spot start in place of Purdy

Sep 21st

Jones will start Sunday's game against the Cardinals after the 49ers ruled out Brock Purdy (left shoulder/toe).

#1 QB

Brock Purdy: Officially out for Week 3

Sep 21st

The 49ers downgraded Purdy (toe/shoulder) from questionable to out for Sunday's game against the Cardinals.

#1 WR

Jauan Jennings: Downgraded to out for Week 3

Sep 21st

The 49ers downgraded Jennings (ankle/shoulder) from questionable to out for Sunday's game against the Cardinals.

#3 WR

Kendrick Bourne: Should see uptick in snaps Sunday

Sep 21st

San Francisco head coach Kyle Shanahan said that Bourne is "probably" going to be a starting receiver for the team in Sunday's game against the Cardinals with Jauan Jennings (ankle) listed as questionable but set to be inactive for the Week 3 contest, Matt Maiocco of NBC Sports Bay Area reports.

#2 LT

Spencer Burford: Lands on IR

Sep 20th

Burford (knee) was placed on injured reserve Saturday.

#7 WR

Malik Turner: Elevated to active roster

Sep 20th

The 49ers elevated Turner from the practice squad to the active roster Saturday.

#3 QB

Adrian Martinez: Elevated again

Sep 20th

The 49ers elevated Martinez from the practice squad to the active roster Saturday.

#2 FS

Siran Neal: Clears concussion protocol

Sep 19th

Neal does not have an injury designation for Sunday's game against the Cardinals, Tyler Drake of ArizonaSports.com reports.

#1 FB

Kyle Juszczyk: Clears concussion protocol

Sep 19th

Juszczyk does not have an injury designation ahead of Sunday's matchup against the Cardinals, Tyler Drake of ArizonaSports.com reports.

#2 LDE

Yetur Gross-Matos: Taken off injury report

Sep 19th

Gross-Matos does not have an injury designation ahead of Sunday's game against the Cardinals, Tyler Drake of ArizonaSports.com reports.

#6 WR

Jordan Watkins: Could be headed for lengthy absence

Sep 19th

Watkins (calf) has been ruled out ahead of Sunday's game against the Jaguars, Matt Barrows of The Athleticreports.

#2 LG

Ben Bartch: Lands on IR

Sep 17th

Bartch (ankle) was placed on injured reserve Wednesday, Noah Furtado of the San Francisco Chronicle reports.

#9 WR

Brandon Aiyuk: Spotted running

Sep 17th

Aiyuk (knee) did some running while his teammates were practicing Wednesday, Nick Wagoner of ESPN.com reports.

#3 TE

Brayden Willis: Bumps to active roster

Sep 17th

The 49ers signed Willis to the active roster from the practice squad Wednesday.

#1 K

Eddy Pineiro: Misses PAT in Niners debut

Sep 15th

Pineiro went 2-for-3 on extra-point attempts and made both of his field-goal tries during the 49ers' 26-21 win over the Saints on Sunday.

#4 WR

Marquez Valdes-Scantling: Logs nine snaps on offense

Sep 15th

Valdes-Scantling failed to bring in his only target in Sunday's 26-21 win over the Saints.

#1 TE

Jake Tonges: Nabs four receptions Sunday

Sep 15th

Tonges finished with four receptions (on five targets) for 31 yards in Sunday's 26-21 win over the Saints.

#2 TE

Luke Farrell: Scores first TD of career

Sep 15th

Farrell brought in two of three targets for 15 yards and a touchdown in Sunday's 26-21 win over the Saints.

#1 MLB

Fred Warner: Does it all vs. Saints

Sep 15th

Warner recorded 11 total tackles (seven solo), one pass defended, one forced fumble and one fumble recovery in Sunday's 26-21 win over the Saints.

#3 RB

Isaac Guerendo: No carries in Week 2 win

Sep 15th

Guerendo returned two kickoffs for 47 yards and was not used on offense in Sunday's 26-21 win over the Saints.

#2 RB

Brian Robinson: Handles seven touches Sunday

Sep 15th

Robinson rushed six times for 20 yards and caught his only target for a loss of one yard in Sunday's 26-21 win over New Orleans.

#2 WR

Ricky Pearsall: Four grabs in Week 2 win

Sep 14th

Pearsall caught four of six targets for 56 yards in Sunday's 26-21 win over the Saints. He also rushed once for minus-4 yards.

#1 RB

Christian McCaffrey: Finds end zone in Week 2 win

Sep 14th

McCaffrey carried the ball 13 times for 55 yards and caught six of seven targets for 52 yards and a touchdown in Sunday's 26-21 win over the Saints.

#1 LT

Trent Williams: Suiting up Sunday

Sep 14th

Williams (knee) is active for Sunday's matchup with the Saints, Briana Jeannel of the 49ers' official site reports.

#4 TE

George Kittle: Move to IR official

Sep 9th

The 49ers placed Kittle (hamstring) on injured reserve Tuesday.

#5 WR

Skyy Moore: Handles return duties for SF

Sep 8th

Moore did not receive a target and returned five combined kicks for 63 yards in Sunday's 17-13 win over Seattle.

#1 RT

Colton McKivitz: Inks extension with San Francisco

Sep 8th

McKivitz signed a three-year, $45 million extension with the 49ers on Monday, Adam Schefter of ESPN reports.

#1 SS

Marques Sigle: Gets starting nod Week 1

Sep 7th

Sigle will be the 49ers' starting safety against the Seahawks on Sunday, Matt Maiocco of NBC Sports Bay Area reports.