The Latest 49ers Odds For NFL Season 2025
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San Francisco 49ers
0-0 (0-0 in the NFC West)
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49ers Week 1 Matchup
Sunday at 4:05 pm EST
San Francisco 49ers
23.5 Pts
23.5 Pts
@
Seattle Seahawks
22.0 Pts
22.0 Pts
Moneyline
DraftKings Spread
DraftKings Over Under
DraftKings PROBABILITY with vig removed
49ers Win (-125)
53.2%
Seahawks Win (+105)
46.8%
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Projected Record: 11-6 (3-3 NFC West)
Win Totals
DraftKings Wins
PROBABILITY with vig removed
Over 10.5 Wins(110)
45.7%
Under 10.5 Wins(-130)
54.3%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
No changes have been recorded yet.
Super Bowl
DraftKings LINE MOVEMENT
NFC Champ
DraftKings LINE MOVEMENT
NFC West
DraftKings LINE MOVEMENT
49ers Injury Report
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49ers News
OG
Ben Bartch: Activated from NFI list
Jul 31st
Bartch (quadriceps) was activated from the active/non-football injury list by the 49ers on Thursday.
CB
Deommodore Lenoir: Missing time with hip injury
Jul 31st
Lenoir is expected to miss the next few practices with a hip injury, David Lombardi of SFStandard.com reports.
WR
Andy Isabella: Signs with San Francisco
Jul 31st
The 49ers signed Isabella to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.
WR
Marquez Callaway: Finds work with San Francisco
Jul 31st
The 49ers signed Callaway to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.
QB
Carter Bradley: Joins San Francisco
Jul 31st
The 49ers signed Bradley to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.
49ers Depth Chart
Quarterback QB
Running Back RB
Wide Receiver WR
Fullback FB